Thursday, January 27, 2011

Weight And Size In America

Psychosis: Bartolomé Llopis

We intend to refer in this entry to the concept of axial syndrome of psychosis , as developed by Bartolomé Llopis, staunch advocate of the concept of single psychosis , whose importance and presence has alternately flourished and declined throughout the historical evolution of psychiatry and psychopathology. We will continue to do the text only psychosis. selected writings, that collects several works by this author. Llopis argues that the crucial problem of psychiatry is whether psychological symptoms are produced and set in each case for a particular cause or pathogenetic represent only existing response options that can be shown by various causes. The author denies the specificity of the real physical symptoms and helped to revive the theory of psychosis only (or unit, others prefer translation). In the words of Llopis, speaking of psychosis is only wants to express that mental symptoms are the same in diverse diseases, the brain, which directly or indirectly dependent condition always those symptoms, you have the same answers to all attacks, like other organs. Moreover, among all these responses there is a continuity, a transition insensitive, so that the various psychotic symptoms represent only varying degrees of intensity of the fundamental disorder.

Commenting historical background of the thesis of the single psychosis, Esquirol says: " Madness successively and alternatively can affect all these forms: mania, mania and dementia are replaced, are complicated in the course of the same disease, same individual. " For him, mania, mania and dementia are not disease entities but only forms, ie, syndromes, and also be a transition from one to another. In this sense, can be considered to Esquirol as one of the first representatives in modern times of the thesis of the single psychosis. Speaking of the causes of insanity, said that its etiology are so numerous and varied. But considering the etiology is essential for delineation of disease entities. If madness is due to so many and varied causes, is because it is a disease entity but a syndrome. Otherwise, it would have so many follies as etiological factors. Esquirol claimed that madness, in the singular, it can be produced by many different causes and may also manifest itself in diverse ways. According to Llopis, could express the thought of Esquirol saying that psychosis is a syndrome common to many diseases and that this syndrome may adopt or pass on to various forms, and also that Madness is a basic or fundamental syndrome, divisible into syndromes subordinates. Georget defended the view that mental illness was a brain disease idiopathic with a wide variety of demonstrations, which would not, however, independent diseases. He said: " can see a series of intermediate types, ensuring that there is a seamless transition between both forms of l mint condition." Neumann says in his treatise published in 1859: "We can not believe real progress in psychiatry until the general has taken the decision to throw overboard all classifications ." Also: " There is only one kind of mental disturbance and call madness." In the opinion of this author, they do not form any mental disturbance, but only stages of one and the same pathological process. Neumann was able to recognize and highlight clearly the difference between isolated events and complex symptomatic manifestations, on the one hand, and actual pathological processes, on the other. Called "elements" to those isolated events, as opposed to the real disease, which he described as "processes." He said: "The true diagnosis has nothing to do with the naming , that is knowledge of the individual case, it is the product of abstraction, and indeed an abstraction based on analogies premature. " The idea of \u200b\u200bpsychosis only reached its peak under the influence of Griesinger, who begins his treatise published in 1861 saying that insanity is not, in itself, rather than a symptom, this symptom can not be claimed more that a brain disorder. Regarding the rankings, said: " The establishment of the various groups of mental illness can only be done from a symptomatic point of view "and" can be justified only from existence. "

According Llopis, the decline of the concept of psychosis really only seems to start work Hoffmann (1861) and Snell (1865) that break with what they see as the dogma of the exclusively secondary paranoia, describing the " monomania as a primary form of mental disorder ." Griesinger accepted a "primary paranoia" and Westphal in 1876, made his classic description of the disease, emphasizing the abnormality of considering representations and affective disorders as incidental or unimportant. Thus began a process that collapsed, at least temporarily, the notion that delusions are always secondary to mood disorders, a concept that was one of the strong pillars of the theory of psychosis only. Nevertheless, the decisive blow against the single psychosis was struck by the tremendous work of nosographic Kraepelin, on the other hand, had the predecessor to Kahlbaum . Kraepelin laid causal-symptomatic principle, whereby each cause of the disease is linked to a certain psychological symptoms. It is not, however, that each corresponds a specific disease process status box. Symptomatological differences for the various diseases are much finer, much more difficult to perceive than those between the various categories of state (melancholy, mania, stupor, delirium, paranoia ...). The differences between them are so obvious that their separation has not ever offered great obstacles. In contrast, the finding of specific physical symptoms for various disease processes is a task fraught with difficulties. You can not do directly, regardless of pathological processes, a classification of major psychiatric symptoms. According to Kraepelin, natural syndromes, ie, those who can differentiate a direct and spontaneous, are accessories for the recognition of disease entities, while small symptoms of the syndrome accessories in total in which they appear, may be critical to the diagnosis of underlying disease. Also admits that the difference in disease processes is often most clearly highlighted in the course of the disease. He says: " precisely why the consideration of the progress and completion of the mentally ill seems to me extremely important for delimitation. " With Kraepelin, reaches its climax psychiatric systematics based on the specificity of psychiatric symptoms and collapses completely unique concept of psychosis, and seriously undermined by the theft of your emotional base to the paranoia.

Subsequently, the first-symptomatic etiology Kraepelin was subjected to multiple attacks. As pointed out by Llopis, after the collapse of the theory of psychosis only appeared four ideological currents that converged to the resurrection of this thesis: the recognition of the specificity of psychological symptoms (Hoche, Bonhoeffer, Specht, Hartmann, Bumke, etc. ), the application of evolutionary perspectives to the study of nervous system disorders (Jackson, Monakow, Janet, Ey, etc.) overcoming the consideration atomistic psychology unit of psychic life (psychology of the whole , psychology of form, etc..) and also overcome the old doctrine brain locations of mental functions and views that emphasize especially the importance of joint activity throughout the brain (Flourens, Lahsley, Goldstein, etc..). Common to all these trends is a tendency synthetic, unifying, which openly opposes the momentum analyzer, specific and distinctive characteristic of all attempts at classification. After this overview, it is clear that since the beginning of scientific psychiatry have taken two approaches to the problem of mental disorders: a synthetic, meeting the symptoms in the great unity of the so-called single psychosis, which represents the same response but with varying degrees intensity, the more varied attacks, another analytical, which breaks down and distributes multiple psychotic symptoms specifically determined by the various pathogenic causes. Both tendencies have fought, sometimes with burning, but as stated Jaspers, " instead of fighting, could be complemented ." Llopis argues that there really is no argument between the two compatible. Nor the necessary classification of mental illness can destroy the unity of psychic disorders flowing nor the recognition of this unity means no obstacles to psychiatric nosology. Mental diseases called leads to impaired mental activity, which may have varying degrees of intensity. When all these conditions is what has been called "one psychosis", and Llopis, to avoid confusion, has proposed to call " axial syndrome common to all psychoses ." The varying degrees of this syndrome are not pathognomonic axial any disease, but could support a possible causal disease, especially if we consider also its temporal variations, ie the course of psychosis.

Llopis Turning to what he calls his own concepts about psychosis only, it is necessary to clarify what is meant by syndromes of the state and content of consciousness. considers Awareness as the ability to know and knowing is always distinctions or differentiations. Knowing is one thing to distinguish, to separate what is not herself. There is no mental act than an act of knowledge. Consciousness and psychic activity are therefore synonymous concepts. Call state of consciousness to the degree of clarity or lucidity, which is expressed by a greater or lesser capacity to know. Content consciousness is all that is known (noticed sense, perceived, apprehended) by consciousness. Contents pathological consciousness can not be more than those that reflect the abnormal situation of the organism itself, that is, in general, any content provided not by the external senses, but by the internal sensitivity for the cenesthesia. In contrast, pathological states of consciousness pertain to both external and internal stimuli. The pathological contents of consciousness can not be regarded indeed as psychological disorders. Their awareness is limited to take cognizance of a disorder of the body.

However, the fact that the syndromes of the content of consciousness are not mental disorders per se, does not mean lack of extraordinary importance in the shaping of the psychotic disorders, ie what Llopis called syndromes mental picture. The mentally ill do not express an immediate and pure content, ie, feelings, plastic materials offered to the activity of conscience, nor the same activity, what they say are the works that those materials build their awareness. In such works, or psychotic symptoms are integrated, for both content disorders such as mental activity or state of consciousness. The fact that these works are also still qualify as content ( psychotic content) should not lead to confusion. The psychotic episodes are, in effect, rather than psychological content, but psychic contents which has left its stamp on disorders of consciousness. To be designated as containing psychotic need to reveal the existence of a disorder of the state of consciousness. Table psychological syndromes are psychotic symptoms such as is an empirical observation. Now if we consider the essence of any mental disturbance as a projection experiences the outside world caused by internal stimuli, we can formulate the following questions: What is the degree or intensity of the projection? What is projected? Thus Table psychotic breaks in its two constituent factors: the syndrome of the state and the syndrome of the contents of consciousness. The transformation of the contents or primary disease (syndromes of the content of consciousness) in psychotic or secondary content (Table psychological syndromes) is performed, then, under the action of the true and only conditions of psychic activity, which are the syndromes call status consciousness. This action metamorfótica mental disorder on the contents of consciousness seems to be regulated by two fundamental principles: principle of "like" or metaphor and introversion principle.

The principle of "like" or metaphor explains that the somatic sensations produced by stimuli internal, normal or pathological, can not be analyzed and described if not comparing with sensory impressions caused by external causes. Pellagra patients, for example, describe their pain and numbness: "I ran like snakes ... as if a dog bit me ... as if it were on fire ...". They are images, metaphors of the external world with which patients express their inner impressions miss. The same applies to those internal anomalies, more diffuse, which we perceive as feelings or emotions: "I notice a sense of unease, as if danger threatens me ...". The feeling is invariably adequate image of the outside world to the affective. Kinesthetic impressions are always linked to representations of the external world. These representations or images arise automatically, aroused by the inner impressions, and serve the normal subjects to describe metaphorically, through the phrase "as if" the particular quality of those impressions. But these individuals do not confuse the feeling with the image, the internal with the external reality with the metaphor.

Moreover, the principle of introversion is explained from the point of view that any disruption psychic is a reduced ability to learn in a decreased level of consciousness. As this decline is occurring, patients are losing touch with the outside world and immersing himself in his own inner world. Gradually abandon the objective world, common to all, and are enclosed in increasingly subjective world, individual. As to the introversion simultaneously be losing the ability to know, to differentiate, prove that parallel to the loss of contact with the outside world, they will be breaking down the boundaries between the sensations and representations, internal and external, the subjective and the objective, reality and metaphor. Patients lose awareness of the metaphorical significance as before, in the experience of "as if" they lived properly as a metaphor, now living as a reality.

Doubt is the great achievement of man because it involves self-knowledge, ie differentiation between self and world, or between an inner and outer world. When human consciousness declines with fatigue, sleep, or illness in psychosis, man loses the privilege of the doubt and sinks an unshakable security. This security is all the more regrettable that due to the Introversion principle, the content offered to consciousness are becoming less objective picture of the outside world and more and more images created by your own imagination under the influence of internal stimuli. We tend to project into the outside world, to live as if they were objective realities, all kinds of subjective fantasies. Llopis Cree only different degrees of such a projection (which does not express, in short, more than a car and alopsíquica disorientation, an inability to discriminate between the given objectively in the outside world and given only in the self) can explain purely quantitative transitions between the different syndromes of the state of consciousness, despite its apparent qualitative differences.

From their point of view, neurosis can not be considered rather than syndromes content consciousness. It is not in them of true changes in mental activity, but affective states, among which is a particularly prominent anxiety. These affective states are only the expression subjective somatic disorders and the fact that the fundamental somatic disorder lacks a clear objective expression does not mean it does not exist. The fact that arouse affective disorders, depending on the experience of "as if" representations or memories (biographical anecdotes) easily leads to the error of confusing cause with consequence. As for affective syndromes, syndromes are considered content of consciousness that do not involve any disturbance of mental activity. However, longtime supporters of psychosis only consider melancholia and mania as phases of this psychosis. This apparent contradiction is explained by the process of introversion of consciousness. At the beginning of this process, the consciousness becomes less intellectual and more emotional, affective content then dominate over all other possible contents of consciousness. The more advanced the process more intense psychotic introversion and acquire predominance emotional content, but as simultaneously launches the mechanism of projection, the affections are clad increasingly apparent objectivity, it covers an increasingly external events alleged plot, so that these alleged events (paranoid ideas, hallucinations ...) acquire hegemony in the box psychotic while those with truly primary and fundamental, reduced almost to vanish, apparently, to mere reactive consequences. Thus, although the affective syndromes may persist through all stages of psychosis may manifest itself only with evidence in the initial stage. It should be stressed that melancholia and mania are psychic contents and, therefore, are not genuine stages of psychosis, much less subsequent stages. What happens is that in the first stage of the psychosis which reveals more clearly the emotional situation, regardless of the patient, may occur it is neither sad nor happy, but indifferent, what should be possible to poverty or lack of kinesthetic stimuli.

Referring to the paranoid syndromes, and within the normal psychic is a tendency to project one's own feelings in the outside world, ie to distort the true picture of the world in favor of their own emotional situation. For this projection becomes more severe disease requires a decrease in the level of consciousness. In the most serious obsessions, the projection still faced with an emotional understanding of reality, with a critical consciousness, which can reject objectively unreasonable or absurd occurrences or representations awakened by affection. However, paranoid ideas, the projection is stronger and no longer question the external justification of such occurrences, which are experienced as if they were the exact meaning of external reality. Typical of the paranoid ideas is that the projection of subjective state, without actually modifying the sensory image of the external world, gives it a peculiar significance in relation to self. Consciousness is lost chance and all people live as if you were encouraged by certain designs, which can be favorable or hostile, as the subject's emotional state. Affection is the force that gives direction and paranoid ideas, resulting in a factor essential constituent of any idea of \u200b\u200bthis nature. But affection is not enough, with addition of a decreased level of consciousness that the experiences aroused by the affection is projected onto the external world, ie to live as if they are justified not by the inner reality, but by external reality. The old debate about the origin primarily emotional or intellectual paranoia would be ill-conceived, as both disorders (the content and the state of consciousness) are also indispensable for the genesis of paranoia.

About hallucinatory syndromes, Llopis insists that all psychopathological phenomena, even the most disparate, can be explained by only quantitative variations of a single critical condition. Thus attributed the passage of paranoid ideas to hallucinations, ie, thought disorders to disturbances of perception, for the simple progressive decrease in the ability to know. The thoughts and perceptions are yields of a single function, which is the ability to learn. Perceptions are simple knowledge of the physical presence of things while thoughts are knowledge of the meaning or significance of such transcendent things. Thus, disorders of thought and perception are not qualitatively different, but only modes of expression of different degrees of intensity of a single critical condition.

Moreover, the author argues also the analogy between psychosis and sleep, noting that the process of introversion, loss of contact with the outside world, to plunge into the inner, is a phenomenon common to the madness and sleep. Awareness or ability to learn can not be altered more than one sense of the decline in their yields. It does not matter that this alteration is caused by abnormal pathological factors for the normal action of physiological fatigue. The axial syndrome common to all psychoses or series of mental states constituting the single psychosis, there is therefore nothing but the same sequence of states of consciousness that we in the transition from wakefulness to sleep.

box because everything can be decomposed into a psychotic syndrome and content-based state of consciousness , we must consider what the relationship between each of these two kinds of syndromes and diseases that produce them. Syndromes of the content of consciousness are merely subjective manifestations of disease, depending on both the soma sensitive sites that have been attacked by the disease. Refers here to involvement of different receptors or sensory systems, both in the brain itself as anywhere in the body. In contrast, syndromes of the state of consciousness correspond to different degrees of reduced ability to learn, and this ability depends on the joint activity of the brain. Their cause must be sought in those pathogenic insults affecting the unitary and global function of the brain. Syndromes of the state of consciousness correspond to different degrees of what Jackson called "uniform solution nervous system, in which the whole system is under the same corrupting influences, although the most recent ones under higher yields, "yield" in the first place and there is a progressive and homogeneous regression to lower functional levels. The declines at progressively lower levels of functional activity of the nervous system does not reflect a different location within it, but just a different intensity, a different degree of "harmfulness" of pathogenic noxa. In short, the syndromes of the content of consciousness depends on the particular affinity for locating the pathogenic noxa with respect to the various parts of the body, while the syndromes of the state of consciousness depend on the degree of psychological harm that noxa. That is different origins, including syndromes of the state of consciousness there are only quantitative differences that allow their management in a continuous series (the single psychosis or axial syndrome common to all psychoses), while in the syndromes of the content of consciousness are qualitative differences as they may affect different sensory qualities. Within the general specificity of these syndromes, the contents of consciousness have greater value in the differential diagnosis. Both syndromes show, at least within certain limits, certain trends causal disease processes, and such trends is much more affinity localizatoria constant and characteristic that the harmfulness psychic. The diagnostic value increases dramatically if you take into account the combination of both syndromes in which we have called mental picture syndrome. In such symptoms are units of a higher order, which keep a dual relationship with the organic process grounds, will serve much better to find out. Units of a still higher order syndromes that are psychic box psychotic courses. These express the sequence, ie the sum over time of those pictures. Translate not only the harm and the location of the process but also their temporal variations.

However, only in very exceptional cases we can make a diagnosis with absolute certainty, taking into account only the psychic manifestations disease. In many diseases, especially those that underlie the so-called endogenous psychoses, our inability to discover somatic targets only forces us to diagnose the psychological symptoms. It is certain that we are satisfied many times misdiagnosed. We stop, Finally, in discussions carried out by Llopis about schizophrenia. Believes that under that label is not showing more than a syndrome, or rather, a series of psychopathological syndromes without somatic basis determined. On such grounds as may be determined somatic probably dissolve the nosological concept of schizophrenia in a multitude of heterogeneous. Do not forget that these syndromes are essentially nonspecific and can occur not only endogenous but also exogenous diseases, diseases of somatic bases inaccessible to our means of investigation and in other well-known and well diagnosable. The diagnosis of schizophrenia is always recognition of our inability to discover the fundamental organic disease, it's like hide our ignorance under a label. Many times we are not individually responsible for such failure, because this depends on the state of our science, but many times yes, because the diagnosis is made without depleting the patient's mental status examination, because it gives a specific meaning to the mental symptoms, because syndrome is attributed to a psychic the value of a disease entity.


Friday, January 21, 2011

Klucz Serjny Domount&blade

Medical Progress with vested interests (COUNTRY dixit)

ago For some time we read in the newspaper El Pais article by the Advocate reader Milagros Pérez Oliva. Is this a weekly newspaper, which includes criticism or suggestions from readers on the same day. We recognize that we like to read regularly and which we see now in this post certainly impressed us as you will be with you if you come to the end (we know that the tickets are long, what can we do ...). But unfortunately, as we have said before, we were impressed but not surprised ... Andaman cured of ghosts ...

We
entries in the chamber to be published on the single psychosis of Bartolome Llopis on ethics in Stoic philosophy and its relation to Lacanian psychoanalysis or the conceptual definition of delirium , from a deconstructive analysis the same as the parameters of the DSM-IV ... And I swear it's true.

But remember an old joke about Mafalda, where he saw her (or was it Mickey?) Asking a worker who worked in a hole in the ground: you looking for happiness? And he answered: No, honey, a gas leak ... Mafalda (definitely a she) walked away thinking: as always, the urgent does not leave time for what matters. And that happens to us, which we have been feeling some choking the continued presence of the pharmaceutical industry and their minions in our working environment makes us feel the need tickets like this while the other would be a lot prettier (anyway, if we end up falling hack before the blog page ...).

And then article Mercedes Pérez Oliva, who is worth it:

often arrive in the newsroom studies and apparently rigorous and reliable data, however, may mislead readers or hide advertising or commercial interests. Discovering and avoidance is a duty of rigorous journalism. Who, doctors and patients still have to deal with chronic pain, must have felt a great relief to read that "in the last European Congress of Pain, held in Lisbon, was presented tapentadol (...), the first analgesic that appears in 25 years of a new generation that will mark a before and after ", and" the experts said in Lisbon that begins a new era in the management of difficult acute and chronic pain. " I said Mayka Sanchez COUNTRY contributor to health issues in the article "Pain as the fifth vital sign," published Dec. 22 in Society. Described in the same unfortunate situation: "Despite nine million English chronic pain, only 10% of primary care physicians used measurement scales for better therapeutic approach, an issue that causes up to half of the cases, the pain may become a symptom badly treated ". The conclusion was clear: most doctors do not act properly and most poorly treated patients. To alleviate this situation had arisen Painless Platform, an initiative whose goal was to "sensitize" the doctors and the society " with medical advances, pain can and should be monitored.

Several
Doctors called the Ombudsman to complain about being given such a bad image of your work without citing the source of statistics. But one of them, Enrique Gavilán, Plasencia, saw something else: "I have been searching the main database of scientific studies, the U.S. PubMed bookstore, I reviewed the studies that have been published about this new drug and believe me, the results show that it is far superior to placebo and in any case is very similar in effectiveness to others that there is a lot more clinical experience and its price, I suspect, be much lower. " In its letter to the Ombudsman asked to investigate whether it is a case of surreptitious advertising and conflict of interest.

Mayka Sanchez clarified that the data are drawn from the Guide to Good Clinical Practice in Pain and its assessment of tapentadol is based on the statements made by Anthony Dickenson, one of the specialists who participated in clinical trials at the congress of the European Association for the Study of Pain, held in Lisbon, which she attended. The drug, he says, is supported by "177 articles published in international journals and conferences, all equipped with" an editorial and scientific committee which monitors the accuracy, objectivity and quality of work presented. "To Mayka Sanchez, suspected of surreptitious advertising referred to Dr. Hawk" is a very subjective opinion and not based on the published text, "as he says, are only talking of one of the molecules presented in Lisbon, not to mention your business name. The Advocate, this explanation does not seem enough. All studies on new drugs, including those quoted on the tapentadol Mayka Sánchez, are funded by vaccine manufacturers and sometimes the Congress in presented. On the biases in clinical research and the publication of the results there is ample scientific literature. The work of a journalist is to verify information and avoid bias on the part it may contain.

Was justified introducing this drug as a breakthrough drug "before and after" or "new era" in the treatment of pain? To clarify the professors I consulted Xavier Carner, president of the Drug Evaluation Committee of the English Medicines Agency, and Rafael Maldonado, a researcher at the University Pompeu Fabra working for the National Institutes of Health, USA. Neither considers the drug to be a novelty. Even the laboratory that produced it goes so far as Mayka Sánchez. In the press release in its submission in June states that "shows comparable efficacy to opioids classic" but offers "a more favorable tolerability profile." Nor is new: it has the same mechanism of action tramadol, the same laboratory.

But there is only a matter of exaggeration. The way information is presented justify the suspicions of Dr. Hawk, because it conceals all content comes from a single source, and omitted to disclose that source is, ultimately, the drug manufacturer name . Quote Grünenthal the Foundation of the Platform as driving without pain, but does not say that it belongs to the laboratory Grünenthal Pharma specializes in analgesic therapy, which is funding the campaign platform and the measurement of pain. The report also clarifies that the drug presents a revolutionary part of this laboratory . Only readers already know that lab can guess the relationship.

The information is dangerously scheme of new pharmaceutical strategies used to promote the prescription of drugs, after eradication the outrageous incentives that reward doctors. In fact, doctors are no longer the sole objective of the marketing departments of the laboratories. Now try to influence prescribing by patients themselves. That strategy is to bring out (sometimes even creating) a health problem, mobilizing scientific leaders and if possible, patients with the aim of "raising awareness" about the problem which has the solution .

Given the suspicion with which information is received from the industry, it has been forced to seek indirect forms and greater authority to vehicular activity. For this have created foundations and platforms theoretically independent and nonprofit, composed of academics and specialists, but funded by the industry itself .

All this is present in this case. The report begins by describing the serious problem of pain, based on studies funded by industry, presents to the platform that will fight against this scourge, saying that it is promoted and funded by the lab, and just reporting a drug that appears as revolutionary without saying that it is the same laboratory . For sake of completeness, the holder of the report coincides with the central slogan of the campaign funded by Grünenthal . And not even a novel information, as the very Mayka Sanchez had published three months before the same theme in El País Semanal. The only new thing was the reference to the drug. The report cites the Lisbon conference but does not mention that Mayka Sanchez traveled to the capital invited by the laboratory lusa . Style Book Country establishes the subject: "The newspaper, as a rule, does not accept invitations for processing information. Exceptions will expressly be authorized by management. In the information made after accepting an invitation shall state that the trip has been sponsored.

Over all, the deputy director responsible for Society, Bern González Harbour, said: "The newspaper is becoming the target of a massive flood of reports and studies, many of them partly filled with interesting conclusions at first glance but they lose their legitimacy in the interest checks from its own promoter. Our task is to analyze, identify and submit all the most scrutiny, and filter and publish only what is truly contrasted and objective that is of interest to our readers. The controls have not worked in this case and apologize. This article is an example of what not to do .

far article, emphasis added, repentance and apology from the newspaper and need to reflect, we believe, is all ...


Saturday, January 15, 2011

30 ЯНВАРЯ 10000-12000

About the (depressing) the effectiveness of antidepressants

In the book Inventing mental disorders, several sometimes recommended in this blog, González Pardo and Pérez Álvarez provided by the fact that by 1980 depression was a rare disorder, affecting 50 to 100 people per million, while estimates of the decade just passed The are around 100,000 people per million. If we believe (and we believe because, given the existing evidence seems indeed a matter of faith), as they say from certain sectors of the profession, we are facing a brain disease caused by imbalances in neurotransmission, we should ask what happened in the human brain in these three decades that where before there was a depression, now has 1000. We will respond, no doubt, that what happens is that previously underdiagnosed. That is, as before (in 1980, in the seventeenth century, ie relatively recently that at least one of the authors of the blog remember that year) we had 999 people undiagnosed depression per 1000 patients we have today, , which received no treatment while now they are benefit from it. This would lead to the conclusion that people were much more unhappy or even commit suicide in 1980 than in 2010 but does not seem to have data to suggest such a thing (OK, we admit that the Madrid scene, Moran and jokes could be Naranjito depressive equivalents, but even so, the accounts do not we go ...).

And these figures are more striking when we consider that it is in the 80's when they start to market the new (and expensive ) antidepressants, with the paradigmatic example of Prozac. In medicine we have seen the advent of antibiotics causes a reduction in morbidity and mortality due to infectious processes. Or how the emergence and development of antiretrovirals have been achieved dramatically increased life expectancy in HIV patients. Or how the development of TB drugs TB became a very rare disease. It turns out that the emergence of new (and expensive ) antidepressants, presumably effective and well tolerated ( and, if we did not mention, expensive ) not only fail to reduce the number of depression, but they 1000-fold increase ... We must recognize that depression, a disease for biological neurochemistry nature, behaves more like a sales index powered to infinity for greater glory and benefit of some lucky company (" and why we think of that this comparison ?).

And after these comments, we would dwell on the question of the effectiveness of antidepressants to prescribe (and so many people take). Today, we believe, there remains an unwritten rule of "maybe something help." And because we also note we have used: "a recent match, but I send the antidepressant because maybe something help," you have been kicked out of gigs, but I send the antidepressant because maybe some help " "Their parents have separated, but send him the antidepressant because maybe something help" ... For every difficulty vital, prescribe (and recognize the plural) any antidepressant, often underestimating bothersome side effects such as dizziness, drowsiness, tremors, nausea, sexual dysfunction than common ... And also underestimating side effects very rare but very serious, such as serotonin syndrome ...

Not to mention how we create the role of sick people suffering from difficulties in life that no pill will fix that, instead of having to take up the pieces and find their own resources and support in your environment, leaving our consultations with the message that do not have to work, that his family has to put up if you want to spend all day doing nothing and that has to expect little calm, without taking any decision until a few weeks, the pill will encourage ... And if not encouraged, we will send another ... And if not encouraged, they are changed by two and add lamotrigine ... And if not encouraged and we like him we put aripiprazole, which is also cheaper and safe ... And if we do not like, then we say that you are a hysterical and seeking refuge in psychiatry, but do not remove any of the drugs ...

perhaps exaggerated, but the real base is so real ...

Because if antidepressants in question effectively cured all that we call depression , and also no significant side effects, it would be wonderful (we would take ourselves without hesitation). But what if it turned out are not effective in most of what we call depression but they do have side effects? And not to mention today that price ...

psychiatrists will say that Multiple studies have demonstrated the effectiveness of antidepressants (and please nobody tell us not to believe in the studies but has drug tested and will work, as if there were no placebo effect or bias observer, which seems to be listening to the nearby lava swearing that your detergent cleaner and he knows because he has proven ).

A study published in the New England Journal of Medicine found that in 74 studies registered with the FDA about the effectiveness of various antidepressants, 31% (including 3449 participants) did not were published. 37 studies were published with positive results for the drug tested and with only one positive result was not published. By contrast, studies with negative or questionable results, 3 were published, 22 were not published and 11 were published so that in the opinion of the authors, induced to perceive a positive outcome. In the published literature, 94% of the trials were positive, while the FDA analysis showed only 51% of positive results. Separate meta-analysis of data from the FDA and publications show that the increase in effect size ranged from 11% to 69% for each drug individually, with 32% for total.

magazine PLoS Medicine published a meta-analysis in 2008 to study the relationship between initial severity of depression and the effectiveness of antidepressant medication, based on data provided by the FDA for clinical trials provided by the pharmaceutical industry to gain approval for the indication antidepressant fluoxetine, venlafaxine, nefazodone and paroxetine. The data came from both published and unpublished studies. The meta-analysis included 5 clinical trials with fluoxetine, 6 with venlafaxine, nefazodone and 16 8 with paroxetine, which accounted for a total of 5,133 patients, of whom 3,292 were randomly assigned to receive medication and 1,841 to placebo. The authors analyzed the data, concluded that there was no statistically significant difference in antidepressant response between placebo groups and groups with any of the four antidepressants studied. All groups improved, but no statistically significant difference between active and placebo, except in the most severe cases of major depression, which itself showed an effect that antidepressants placed slightly ahead.

A meta-analysis published in the British Journal of Psychiatry concludes that the studies analyzed show that it is unlikely that there is a significant clinical benefit for antidepressants versus placebo in patients with minor depression.

An article in the British Medical Journal includes a meta-analysis published and unpublished studies of reboxetine. The conclusion is that an antidepressant reboxetine is ineffective and potentially harmful, saying the evidence (correct translation of evidences ) published are affected by publication bias.

A study published in the Journal of the Canadian Medical Association on paroxetine, analyzing published and unpublished studies of treatment of depression in adults, concluded that in moderate to severe major depression, paroxetine was not superior to placebo in terms of effectiveness.

there any other work in the same line but we think it's enough for today. We do not want staff or depressed depress us (lest someone would prescribe an antidepressant because maybe something help ...).